黃芩素 Baicalein
Lipoxygenase inhibitor
Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory *pound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64µM for 12-LO and 1.6µM for 15-LO). Inhibits leukotriene biosynthesis (at higher concentrations) and release of lysosomal enzymes.
PRODUCT PROPERTIES
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Alternative Name:
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5,6,7-Trihydroxyflavone
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MI:
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14: 942
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Solubility:
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Soluble in DMSO, acetone, 100% ethanol or methanol; almost insoluble in water.
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Long Term Storage:
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-20°C
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Use/Stability:
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Subject to oxidation.
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Hazard:
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IRRITANT.
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Handling:
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Protect from light.
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MW:
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270.2
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CAS:
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491-67-8
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Formula:
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C15H10O5
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Purity:
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≥98% (TLC)
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Appearance:
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Yellow to yellow-green crystalline powder.
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普華仕科技發展有限公司 --Puhuashi Technology Development Co., Ltd
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